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1996-02-27
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Document 0242
DOCN M9630242
TI Host cell antigenic profile acquired by HIV-1 is a marker of its
cellular origin.
DT 9603
AU Abbate I; Capobianchi MR; Fais S; Castilletti C; Mercuri F; Cordiali Fei
P; Ameglio F; Dianzani F; Institute of Virology, University La Sapienza,
Rome, Italy.
SO Arch Virol. 1995;140(10):1849-54. Unique Identifier : AIDSLINE
MED/96105342
AB HIV-1 acquires cell membrane proteins during budding. The cell membrane
proteins (CMP) profile of laboratory HIV-1 strains grown in different
host cells was established, by using an immobilized antibody capture
(IAC), to verify whether CMPs present on HIV-1 correlate with its host
cell origin. HIV-1 grown in different cell lines incorporates cell
markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the
distinctive expression of these antigens on the host cells. Furthermore,
also T-tropic and monocytotropic HIV-1 strains display host cell
specific markers, supporting the hypothesis that virus associated CMPs
are a marker of host cell origin.
DE Antigens, CD/METABOLISM Cell Line Cell Membrane/IMMUNOLOGY Human HIV
Antigens/*METABOLISM HIV-1/GROWTH & DEVELOPMENT/*IMMUNOLOGY Membrane
Proteins/*METABOLISM Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).